The Canon Automatic Sensor Cleaning mode does a good job each and every time you turn your 5D Mark II on or off. In Power-up, Power-down, or Manual settings, the Self-Cleaning Sensor Unit uses high-frequency vibrations to shake off lingering dust, and for the most part, this works well. There's some concern that this might also just move the dust around in the chamber, only to land somewhere else. It's a good start, and as photographers know, locations are difficult enough on gear, none more so than keeping your sensors clean. It's either that or consider spending way too much time in Photoshop with the Clone and Patch tools to delete the spots.
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